Senior Scientist, DMPK

Join our innovative research and early development (ReDev) team and dedicate oneself to advancing oligonucleotide therapeutics. We seek a Ph.D. scientist with deep knowledge and hands-on expertise in pharmacokinetics and/or drug metabolism. As a representative of the drug metabolism and pharmacokinetic (DMPK) department, you will work collaboratively with colleagues across research and early development to discover and develop novel therapeutics. The Senior Scientist will be a passionate, highly motivated individual and team player who will utilize strong scientific knowledge and problem-solving skills to understand drug absorption and disposition mechanisms and integrate nonclinical data quantitatively to inform clinical development plans.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

* Develop and execute DMPK strategies: Formulate and implement DMPK strategies that align with our platform, program objectives, and overall company goals to support robust pipelines and facilitate successful global drug registration.
* Represent the DMPK function: Collaborate with Research, Toxicology, Bioanalysis, Clinical Pharmacology, Nonclinical Writing, and Regulatory Affairs to understand absorption and disposition characteristics and mechanisms of novel small-interfering RNAs (siRNAs), apply pharmacokinetic (PK) and pharmacodynamic (PD) principles to guide pharmacology and toxicology study designs, and enable quantitative PK-PD data integration to ultimately influence clinical development plans and to accelerate drug discovery and development processes.
* Design, execute, analyze and interpret DMPK results: Be a doer in conducting experiments and analyzing and interpreting the data, be a problem solver and take initiatives to solve DMPK-related challenges.
* Support regulatory submissions: Write PK, PK/PD, and toxicokinetic (TK) study reports and other regulatory documents to support regulatory filings and address regulatory inquiries.

Qualifications

* Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmacology, or a related field with 3+ years of pharmaceutical industry experience.
* Deep understanding of pharmacokinetic and drug metabolism principles.
* Demonstrated ability of applying model-based approaches for quantitative data integration and/or human dose projection is required.
* Proven ability to apply scientific principles and critical thinking to solve scientific challenges in a timely and effective manner.
* Strong interpersonal, written, and verbal communication skills, with a demonstrated ability to collaborate effectively in a team environment.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.