Scientist, RNAi Discovery

The Research Organization at Alnylam is seeking a Scientist to join our Research Analytics team. The Scientist position in Research Analytics is part of the RNAi discovery team and will contribute to the further exploration of RNAi therapeutics. The Research Analytics team focuses on growing a better understanding of the distribution and delivery, the activity, and the stability of siRNA and siRNA-conjugates using a multifaceted analytical approach.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

* Design in vivo and in vitro studies to understand activity, stability, and distribution of siRNAs and siRNA-conjugates. Collaborate with internal biology teams in the characterization of in vivo and in vitro samples using multiple analytical techniques. Leverage in-depth analytical characterization of novel molecules to guide new chemistry designs.
* Discover and evaluate novel analytical techniques to increase sensitivity and detection limit of siRNA therapies.
* Assist in the establishment of a modality-agnostic analytical lab to support our growth into new chemical space.
* Work closely with Early Development team to establish/optimize DMPK methods and coordinate method-transfer to relevant teams.
* Participate in cross-functional internal meetings and communicate relevant information to Research & Development.
* Communicate results with key stakeholders throughout the organization.

Qualifications

* Ph.D. (0-3 years), Masters (3-6 years) or BS (7-10 years) in chemistry, biology, biochemistry, or equivalent expertise areas. Strong focus in analytical techniques preferred.
* Hands-on expertise working with and troubleshooting LCMS Instrumentation. Experience designing and optimizing LCMS methods to solve complex biological problems.
* Broad experience with multiple analytical techniques including immunoprecipitation, cell/tissue extraction, PAGE, WB, Spectroscopy, HPLC, and MS, and utilizing these techniques to answer fundamental questions.
* In-depth knowledge of and experience with oligonucleotide therapeutics (siRNA, ASO, mRNA, or gene therapy) or peptide/protein therapeutics with focus in the relevant analytics.
* Ability to work within cross-functional teams and work as a team player. Possess collaborative mindset with excellent verbal and written communication skills, excellent presentation skills, and attention to detail.
* Ability to recognize impactful areas of research and organize both individual and team efforts to investigate using a broad range of techniques.

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.