Senior Manager, QSP & Data Analytics

Sarepta Therapeutics
United States, Massachusetts, Cambridge
215 First Street (Show on map)
Jan 22, 2025
Why Sarepta? Why Now? The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne. We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas: Physical and Emotional Wellness Financial Wellness Support for Caregivers For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us The Importance of the Role Join us in shaping the future of drug development through innovative quantitative systems pharmacology (QSP) and advanced data analytics. As a Senior Manager of QSP & Data Analytics, you'll be at the forefront of applying mechanistic modeling to bridge preclinical insights and clinical outcomes. You'll develop and implement QSP models that integrate disease biology, drug mechanism of action, and patient variability to guide critical drug development decisions. The role provides quantitative support across the development spectrum - from translational strategies and early clinical development to product registration. You will also leverage modern data analytics and AI/ML approaches to extract insights from diverse biological and clinical data sources. Working with cross-functional teams, you will transform complex biological systems into mathematical frameworks to advance life-changing medicines. The Opportunity to Make a Difference Drive therapeutic program success by designing and developing mechanistic QSP models that reveal crucial insights about disease biology and drug-system interactions across therapeutic areas Shape critical development decisions by applying QSP approaches to tackle challenging questions about dose selection, study design, and patient population targeting Transform our understanding of drug behavior by integrating preclinical and clinical data through innovative model-based analyses that bridge the translational gap Build confidence in model-based approaches by preparing clear, scientifically rigorous regulatory documentation and responses to health authority questions Enhance our modeling capabilities by implementing cutting-edge data analytics, AI/ML solutions that complement and strengthen QSP strategies Accelerate analysis workflows through development of automated tools and intuitive visualizations that communicate model insights effectively Champion quantitative approaches by representing modeling analyses in cross-functional teams and translating technical results into actionable insights Advance the field of QSP by contributing to scientific publications and presenting at key conferences More about You PhD in bioengineering, chemical engineering, biophysics, computational biology, mathematics, pharmacometrics, pharmaceutical sciences, or related disciplines that combine biological systems, mathematical modeling, and computational methods. 2+ years of experience working at the interface of quantitative sciences and drug development Strong background in QSP modeling with demonstrated ability to translate mechanistic understanding of biological systems into mathematical frameworks, complemented by experience in data analytics and pharmacometrics approaches Familiarity with modern data analytics and AI/ML approaches to support model development and data analysis is a plus Strong programming experience in at least one language (Python, MATLAB, R, C, C++, etc.) including proficiency with numerical computation, data analysis, modeling, and visualization libraries (e.g., NumPy, SciPy, Pandas, dplyr, ggplot, SimBiology) Experience with pharmacometrics software (e.g., NONMEM, Monolix) is a plus Excellent written and verbal communication skills with demonstrated ability to collaborate effectively in cross-functional teams What Now? We're always looking for solution-oriented, critical thinkers. So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply. #LI-Remote #LI-TD1 This position is remote. However, you will be expected to work on site at one of Sarepta's facilities in the United States and/or attend Company-sponsored in-person events from time to time. The targeted salary range for this position is $132,000 - $165,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.