Senior Scientist I (Analytical Chemistry)

Exelixis
paid holidays, sick time, 401(k)
United States, California, Alameda
Mar 21, 2025
SUMMARY/JOB PURPOSE: The successful candidate will be responsible for day-to-day small molecule separation, separation and characterization activities using industry-leading chromatography tools for research and development projects. The successful candidate will also be responsible for managing external vendors and service providers for laboratory instrument maintenance, troubleshooting and technical/process development to optimize analytical workflow efficiency and throughput. ESSENTIAL DUTIES AND RESPONSIBILITIES: Perform high throughput compound library purification using LCMS detection and automation software. Perform separation, purification, analysis and scale up purification of small molecule compounds from medicinal chemistry synthesis including chiral separation. Use chromatographic methods including HPLC/UPLC, LCMS and SFC to separate compounds with complex matrices (problem solving). Ability to use automated liquid handler robots to perform sample preparation pre and post purification. Perform data analysis and prepare analysis report under supervision. Participate in group, project team and departmental research meetings. Maintain laboratory notebooks in accordance with company policies and practices. Comply with safe laboratory practices and EH&S guidelines. SUPERVISORY RESPONSIBILITIES: No supervisory responsibilities. EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: Ph.D. in analytical chemistry or related discipline with zero or more years of chromatography experience related to drug discovery; or, MS in analytical chemistry or related discipline and a minimum of five years of chromatography experience related to drug discovery; or, BS in analytical chemistry or related discipline and a minimum of seven years of chromatography experience related to drug discovery; or, Equivalent combination of education and experience. Experience (desired): Experience using LCMS, UPLC and SFC in drug discovery setting Experience with purification and characterization of small molecule compounds Experience with automation for liquid handling processes Knowledge/Skills: Knowledge of automatic liquid handler/Robotics and related data processing software Strong knowledge of small molecule separation by modern chromatographic techniques such as Reverse Phase LC/UPLC, LCMS and SFC. Strong knowledge of LC, LCMS and SFC instrumentation Good interpersonal skills, flexibility and works well within a team environment Excellent written and verbal communication skills WORKING CONDITIONS: Discovery/Alameda: Environment: primarily working in laboratories or in office Travel as required (to be less than 10%) #LI-MB1 If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us! Our compensation reflects the cost of labor across severalU.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this positionis $116,000 - $165,500 annually. The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors. In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year. DISCLAIMER The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job. We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.