Postdoctoral Fellow

Position: Postdoctoral fellow position in functional genomics of neuronal-glial mechanism and drug targets for neurodegenerative dementias. Rexach Lab, UCLA Neurology, Neurogenetics, Human Genetics.

Job Description: Seeking an outstanding applicant with strong research track-record for a competitive post-doctoral fellowship in functional genomics of neurodegenerative disease in the Rexach Lab in the UCLA department of Neurology and Human Genetics. The Rexach group uses integrative multiomics analysis, including single nuclear ATAC and RNA sequencing, to identify glial and immune-related drivers of neurodegenerative dementias, and then studies their function in disease model systems, including human iPSC-derived assembloids and organoids. The goal of this work is to identify and validate new therapeutic targets for neurodegenerative dementias, including Alzheimer's disease and related disorders, none of which have effective cures or treatments. This fellow would lead a functional validation and drug target identification using stem cell-derived models and systems biology to integrate multiomic data generated from models with primary human disease brain data. Salary range is $66737-$80034

Job Duties: Developing, validating and implementing iPSC models of neurodegenerative disease traits and employing them to validate candidate modifiers of disease based on human genetic and functional genetic data.

Skills, Knowledge, and Abilities needed for the position: Experience in cell biology and iPSC modeling of disease is required. Expertise in experimental molecular biology is required, including gene editing and biochemistry. Experience in generating and interpreting data generated by transcriptomics, genomics, proteomics, or related analyses, is preferred. Interest and experience with methods development and innovation is preferred. Experience in basic statistics in required. Experience in advanced statistics for omics research is preferred. Experience in writing first-author scientific manuscripts is required. Strong desire to learn, innovate, discover and collaborate are required. Respect for all colleagues and community is expected and required.

Inquiries: Candidates should send their statement of interest and CV directly to Dr. Rexach for consideration (jrexach@mednet.ucla.edu).

PhD is required

Experience in cell biology and iPSC modeling of disease is required.

• 3-5 required (contact information only)

Only references for serious candidates will be contacted

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct, are currently being investigated for misconduct, left a position during an investigation for alleged misconduct, or have filed an appeal with a previous employer.

• "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, discrimination, dishonesty, or unethical conduct, as defined by the employer.
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