Associate Scientist II, Biology

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture!
Site: www.ptcbio.com

ESSENTIAL FUNCTIONS

Primary duties/responsibilities:

• Under limited supervision, executes experiments as directed by the supervisor and communicates results as part of multi-disciplinary team(s).

• Applies relevant scientific principles and techniques to research problems.

• Maintains detailed laboratory notebooks.

• Maintains broad knowledge of state-of-the-art principles and techniques and may contribute to the identification of new project areas or technologies.

• Presents findings internally and contributes to the publication of the work of the project team in well-established and peer reviewed journals, subject to internal scientific and legal approval.

• May provide technical and scientific input to the project team or research leadership

• Contributes to the development of patent applications as appropriate.

• Complies with all safety requirements.

• Contributes to general lab operations such as:
• Equipment maintenance.
• Identification of capital equipment needs
• Maintenance of clean and uncluttered work areas
• Maintain inventory and ordering lab supplies as needed.

• Specific duties may also include, but may not be limited to, the following:
  • Provides support for high throughput screening including the design of primary assays, the goal of which is the identification of additional hits and new chemical scaffolds.
  • Provides support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays. Profiles selected compounds in additional cells/assays.
  • Provides support for in vivo studies as required.
  • Assists in the development of biologically relevant alternatives to preclinical animal models.
  • Conducts mechanism of drug activity studies

KNOWLEDGE/SKILLS/ABILITIES REQUIRED

• Extensive knowledge and practical experience in flow cytometry with a particular emphasis on analyzing biological samples.
• Hands-on experience in cell sorting techniques, including Fluorescence-Activated Cell Sorting (FACS).
• Experience in handling human and mouse blood samples
• Mammalian tissue culture experience, nucleic acid transfection
• Cell biology and Molecular biology including
• DNA, RNA and protein purification
• Endpoint PCR, qPCR and analysis
• Western blotting

* Minimum level of education and years of relevant work experience.

• Bachelor's degree in a scientific discipline with 5 years' experience or Master's degree in a scientific discipline with over two years of relevant experience.
• Experience (academic or industry) in cell culture required.
• Authorized to work immediately in the United States.

* Special knowledge or skills and/or licenses or certificates required.

• Ability to work productively in a dynamic and fast-paced work environment.
• Strong technical proficiency, scientific creativity, independent thought, and collaborative skills in a cross-functional team environment.
• Knowledge of scientific principles and current relevant scientific literature.
• Analytical thinking and problem-solving skills with adaptability to changing priorities and deadlines.
• Effective planning, organization, and time management skills with ability to support and prioritize multiple projects.
• Proficiency with Microsoft Office, MS Excel, MS PowerPoint, Graphpad Prism.
• Effective verbal and written communication skills.

*Special knowledge or skills and/or licenses or certificates preferred.

• Proficiency in flow cytometry is preferred.
• Immunoassay experience - moderate to high-throughput assays for protein detection using different platforms - western blotting, MSD, ELISA
• Experience in HPLC based biological assay development
• Background in neuroscience
• Experience in assay development

* Travel requirements

Up to 5%

• Office/Laboratory based-position, full-time on-site Mon-Fri.
• Flexible scheduling, including occasional weekend work is required to maintain healthy cell cultures.

EEO Statement:

PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

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