Technical Development Principal Scientist

The Analytical Development organization prides itself on expertise and leadership in the area of process related impurities as well as high throughput analytical testing and data management to support process development and validation activities. We have an exciting opportunity for a talented scientist and NMR expert to join our team.

The position is focused on evaluating protein-based drug samples for leachables and other impurities using quantitativenuclear magnetic resonance(NMR). The role requires the use of a variety of NMR methods to perform process validation, analyze process development samples, quantitate solution components, and demonstrate the comparability and stability of raw materials. A successful candidate will be capable of applying advanced NMR methods and writing custom pulse sequences to resolve the signals of trace impurities in complex solutions.

In addition, the role may involve research involving other NMR application areas, such as real-time release testing, low-field/TD NMR, and protein fingerprinting.

The position requires regular meetings with other stakeholders to develop experimental protocols and strategies, analyze data, and write reports. Other duties include contributing to laboratory maintenance and performing safety inspections.

This job requires strong organizational skills and the capacity to manage multiple simultaneous projects. The ability to plan, schedule, and track work for internal and external teams is essential. Documentation of results and authoring of protocols and summary reports are part of the position, so excellent written communication abilities are needed.

Key Job Functions

* Plan and execute the testing of protein-based drug samples for leachables and other impurities.

* Create customized NMR parameter sets and pulse sequences.

* Provide SME knowledge in the area of quantitative NMR.

* Collaborate with stakeholders to develop benchtop NMR methods, real-time release testing

* Meet with other groups to discuss the design of NMR-based studies.

* Collaborate with other researchers to leverage LC-MS, GC-MS, and ICP-MS data when needed.

* Troubleshoot instruments and methods.

* Author protocols and summary reports.

* Contribute to laboratory maintenance.

Ph.D. in Chemistry, Biochemistry, or related scientific field, or equivalent combination of Bachelor's/Master's and experience. 2+ years of experience and an advanced knowledge of NMR methods and instrumentation. Direct experience with quantitative NMR, operating NMR instrumentation, optimizing NMR parameters, writing or modifying pulse sequences, and analyzing NMR data is required. The candidate must have a good knowledge of general analytical methods, such as quantitative analysis, and possess good verbal, writing, organizational, and interpersonal skills.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 to $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.