Postdoctoral Research Associate - Microbial Synthetic Biologist

Requisition Id16797

Overview:

Oak Ridge National Laboratory (ORNL), the largest science and energy laboratory within the U.S. Department of Energy, conducts cuttingedge basic and applied research to deliver transformative solutions that advance national energy and security priorities.

The Biosciences Division (BSD) within the Biological and Environmental Systems Science Directorate (BESSD) is seeking a Postdoctoral Research Associate to join the Microbial Engineering Group. In this role, you will develop nextgeneration genetic tools for nonmodel microorganisms, enabling precise genome engineering in microbial systems relevant to the emerging bioeconomy. These tools will accelerate our ability to interrogate genotype-phenotype relationships, expand fundamental understanding of microbial physiology, and support the development of design rules for engineering microbes for energy and environmental applications.

ORNL's multidisciplinary research environment brings together expertise across biology, engineering, computing, and environmental sciences to address complex scientific challenges and accelerate the translation of discoveries into realworld solutions.

As a Postdoctoral Research Associate, you will develop genetic engineering platforms for diverse nonmodel microbes, including aerobic and anaerobic community members for microbiome engineering and organisms capable of converting waste plastics and lignocellulosic biomass into domestic fuels and chemicals. Research activities may include creating transformation methods, constructing geneexpression "genetic parts," and developing CRISPRCas and recombineering systems for multiplexed, targeted genome manipulation across broad phylogenetic groups. You will carry out gene deletions and overexpression studies, validate engineered genotypes, characterize physiological impacts, and link genotypes to phenotypes using nextgeneration sequencing, systems biology, and complementary analytical approaches.

This position requires close collaboration with technical support staff and scientific experts in microbiology, systems biology, bioinformatics, bacterial physiology, and analytical chemistry at ORNL and partner institutions. You will design and execute laboratory experiments, analyze quantitative data, and effectively communicate scientific results through publications and presentations.

Major Duties/Responsibilities:

• Perform molecular genetics, synthetic biology, and related experiments
• Work with a diverse team of scientists
• Interface directly with internal and external partners in various disciplines
• Present research results at national scientific meetings
• Publish scientific results in peer-reviewed journals in a timely manner
• Participate in project planning and execution
• Maintain detailed and accurate records
• Acquire and analyze data in keeping with project scheduling
• Take a position of leadership for day-to-day laboratory operations while addressing all of ORNL's environmental health and safety requirements
• Self-assess experimental research skill set and identify weakness and secure learning resources to address these issues
• Ensure compliance with environmental, safety, health and quality program requirements
• Maintain strong dedication to the implementation and perpetuation of values and ethics

Basic Qualifications:

• A PhD in Microbiology, Bioengineering, Chemical Engineering, Molecular Biology, Genetics, or a related field completed within the last 5 years or expected to be completed within the next 6 months at the time of application.

Preferred Qualifications:

• Experience with microbiology, synthetic biology, and molecular genetics, preferably including non-model bacteria
• Experience developing or using CRISPR editing and/or CRISPR inhibition in diverse microorganisms
• Experience growing and genetically modifying anaerobic bacteria is desirable
• Experience analyzing large datasets, including sequencing and 'omics data
• Proven publication record
• Excellent written and oral communication skills
• Motivated self-starter with the ability to work independently and to participate creatively in collaborative teams across the laboratory
• Ability to function well in a fast-paced research environment, set priorities to accomplish multiple tasks within deadlines, and adapt to ever changing needs

For additional information, contact Dr Adam Guss (https://www.ornl.gov/staff-profile/adam-m-guss; email addressgussam@ornl.gov) or Dr Carrie Eckert (https://www.ornl.gov/staff-profile/carrie-eckert; email addresseckertca@ornl.gov) .

Special Requirements:

Applicants cannot have received their Ph.D. more than five years prior to the date of application and must complete all degree requirements before starting their appointment. The appointment length will be up to 24 months with the potential for extension. Initial appointments and extensions are subject to performance and availability of funding.

Letters of Recommendation:

Please submit three letters of reference when applying for this position. You may upload these directly to your application or have them sent toPostdocrecruitment@ornl.govwith the position title and number referenced in the subject line.

Instructions to upload documents to your candidate profile:

• Login to your account via jobs.ornl.gov
• View Profile
• Under the My Documents section, select Add a Document

Security, Credentialing, and Eligibility Requirements:

For employment at Oak Ridge National Laboratory (ORNL), a Real ID compliant form of identification will be required. Additionally, ORNL is subject to Department of Energy (DOE) access restrictions. All employees must also be able to obtain and maintain a federal Personal Identity Verification (PIV) card as mandated by Homeland Security Presidential Directive 12 (HSPD-12) and Department of Energy (DOE) Order 473.1A, which requires a favorable post-employment background investigation.

To obtain this credential, new employees must successfully complete and pass a Federal Tier 1 background check investigation. This investigation includes a declaration of illegal drug activities, including use, supply, possession, or manufacture within the last year. This includes marijuana and cannabis derivatives, which are still considered illegal under federal law, regardless of state laws.

For foreign national candidates:

If you have not resided in the U.S. for three consecutive years, you are not eligible for the PIV credential and instead will need to obtain a favorable Local Site Specific Only (LSSO) risk determination to maintain employment. Once you meet the three-year residency requirement, you will be required to obtain a PIV credential to maintain employment.

About ORNL:

As a U.S. Department of Energy (DOE) Office of Science national laboratory, ORNL has an impressive 80-year legacy of addressing the nation's most pressing challenges. Our team is made up of over 7,000 dedicated and innovative individuals! Our goal is to create an environment where a variety of perspectives and backgrounds are valued, ensuring ORNL is known as a top choice for employment. These principles are essential for supporting our broader mission to drive scientific breakthroughs and translate them into solutions for energy, environmental, and security challenges facing the nation.

ORNL offers competitive pay and benefits programs to attract and retain individuals who demonstrate exceptional work behaviors. The laboratory provides a range of employee benefits, including medical and retirement plans and flexible work hours, to support the well-being of you and your family. Employee amenities such as on-site fitness, banking, and cafeteria facilities are also available for added convenience.

Other benefits include the following: Prescription Drug Plan, Dental Plan, Vision Plan, 401(k) Retirement Plan, Contributory Pension Plan, Life Insurance, Disability Benefits, Generous Vacation and Holidays, Parental Leave, Legal Insurance with Identity Theft Protection, Employee Assistance Plan, Flexible Spending Accounts, Health Savings Accounts, Wellness Programs, Educational Assistance, Relocation Assistance, and Employee Discounts.

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This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.

We accept Word (.doc, .docx), Adobe (unsecured .pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB in size. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment.

If you have trouble applying for a position, please email ORNLRecruiting@ornl.gov.

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply. UT-Battelle is an E-Verify employer.