Staff Research Associate IV

Job Description

Job Summary

The Microinjection Specialist [NT1] performs advanced technical procedures for the Transgenic Core. The Core provides specialized services to UCSF investigators for the generation and preservation of genetically modified mouse models used to support multidisciplinary biomedical research. This position participates in the planning and execution of projects involving the generation of new mouse models; performs specialized mouse embryo manipulation including collection and culture of mouse embryos, pronuclear and cytoplasmic microinjection, embryo electroporation, embryonic stem (ES) cell injection into blastocysts, embryo cryopreservation and recovery, and embryo transfer; participates in mouse breeding and reproductive procedures; monitors animals for health and welfare; prepares reagents, media, solutions, and specialized tools necessary for Core activities; maintains specialized laboratory instruments and equipment in optimal condition; assists with the development and implementation of new and/or revised embryo manipulation and transgenic technologies; troubleshoots technical procedures and outcomes; maintains accurate project and animal records; and communicates with investigators and LARC staff regarding project requirements, progress, and outcomes.

Duties include but are not limited to:

• Independently manages the transgenic [NT2] core for UCSF. Including planning of all technical aspects for planning procedures for generation of new[NT3] mouse lines. Collects and monitors metrics on outcomes of services[NT4] .
• Provides support including surgical support to the rederivation Core as needed.
• Performs duties and provides support to the cryopreservation core.
• Communicate lab and health information to researchers
• Perform advanced surgical and other technical procedures on rodents and other non-rodent species
• Understand and participate in rodent sentinel health or similar programs
• Draft SOP's
• Provide training to Lab or LARC staff. Including advanced surgical training to research staff
• Understand and perform necropsy techniques and other diagnostic or clinical diagnostic techniques
• Understand and perform administrative tasks as needed by LARC
• Generally, assist LARC's animal health and rodent health programs and support LARC veterinarians and UCSF research projects.

Qualifications

Required Qualifications: - Bachelor's degree in biologic or animal science or other relevant scientific field and 3+ years or an equivalent combination of education and experience. - Ability to work to standards required in an AAALAC accredited facility. - Strong written and verbal communications skills which include writing standard operating procedures, communicating rodent health issues and reports, the ability to discuss rodent diagnostic procedures & diseases, and standard treatments. May be required to provide similar support to other species depending on unit needs. - Advanced technical skills with mouse embryo collection, handling, culture, manipulation, or related laboratory techniques. - Either possess or have demonstrated aptitude for quickly obtaining a working knowledge of regulations and animal welfare requirements. - Advanced knowledge and experience in transgenic mouse technology and procedures. - Mandatory participation in department's occupational health monitoring program and pre-employment medical evaluation is required. Preferred Qualifications: - AALAS certification: Laboratory Animal Technologist.