Sr. Principal Scientist, Antibody Engineering

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Neurocrine is further expanding its team of scientists with proven track records, to drive therapeutic pipeline progression from discovery to lead selection within a cutting-edge antibody engineering team
• We are seeking a lead protein engineer responsible for all aspects of construct design, molecular cloning, multi-piece DNA assembly, site-directed mutagenesis, and preparation of libraries
• Responsibilities include generating and screening site-directed, CDR randomization and combinatorial antibody libraries for affinity maturation and developability optimization
• A critical member of the team contributing to characterizing antibodies and antibody-based therapeutics (e.g. affinity, specificity, cross-species binding, epitope determination)
• Will be involved in the engineering of advanced modalities such as muti-specific antibodies and antibody conjugates
• Experience with the design and cloning of antigens for immunization and screening
• Familiarity with structural modeling software such as PyMol or MOE and experience using antibody structure to help mitigate developability issues
• Responsible for understanding experimental data from multiple sources, forming hypotheses, devising strategies, and implementing prioritization to drive projects
• Contribute to the evaluation of emerging molecular biological or biochemical methods, initiate and support new platforms, instrumentation, and technologies related to antibody engineering
• Work cross-functionally with protein biochemists, cell biologists, and gene therapists to achieve project goals
• Other duties as assigned

• PhD in Molecular Biology, Biochemistry, or other relevant discipline and 15+ years of relevant experience in the Biopharma industry
• Knowledgeable in myriad aspects of antibody structure/function including developability screening, effector function (ADCC, ADCP, CDC, and cell-based reporter assays), half-life extension strategies, immunogenicity assessment, and bispecific formats
• Hands-on experience in the design and execution of antibody optimization campaigns using directed evolution screening platforms such as capture-lift, phage display, or yeast display
• Demonstrated mastery of standard molecular biology bench skills, DNA sequence analysis and software, and oligo design coupled with a strong desire to optimize laboratory practices
• Experience building, training, and leading a team of productive bench scientists
• Experience with standard laboratory instrumentation: PCR, centrifugation, DNA quantitation, gel documentation systems, plate readers and washers, liquid handling, etc.
• Familiarity with affinity determination methods (e.g. ELISA, MSD, Octet, Carterra, Biacore, or Kinexa)
• Ability to maintain detailed experimental documentation using Benchling
• Excellent communication and interpersonal skills with an ability to work both independently and in a team environment
• Proficiency in Microsoft Office and DNA sequence analysis software such as Sequencher, Geneious, SnapGene
• Experience with various antibody formats including Fab, scFv, IgG, nanobody, conjugates, and multi-specific derivatives
• Knowledge of standard antibody assay and cloning reagents and preferred vendors
• Experience working with CROs for antibody discovery, expression, purification, and characterization

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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